Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
Abstract
Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation,...
Paper Details
Title
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
Published Date
Sep 7, 2017
Journal
Volume
8
Issue
1
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History