Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

Volume: 8, Issue: 1
Published: Sep 7, 2017
Abstract
Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation,...
Paper Details
Title
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
Published Date
Sep 7, 2017
Volume
8
Issue
1
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