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Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

Published on Mar 1, 2018in Journal of the Science of Food and Agriculture2.422
· DOI :10.1002/jsfa.8650
Arunaksharan Narayanankutty7
Estimated H-index: 7
,
Devika Mukundan Palliyil1
Estimated H-index: 1
+ 1 AuthorsAchuthan C. Raghavamenon6
Estimated H-index: 6
Sources
Abstract
Hepatosteatosis, a form of nonalcoholic fatty liver disease (NAFLD), is being increasingly recognized as a major health burden worldwide. Insulin resistance, dyslipidemia and imbalances in adipokine/cytokine interplay are reported to be involved in the onset and progression of this disease. Use of dietary nutraceuticals in prevention and treatment of NAFLD is emerging. Virgin coconut oil (VCO), a fermented product of fresh coconut kernel, has been shown to impede the development of hepatosteatosis in rats. This study analyzes the potential of VCO to reverse the already developed hepatosteatosis condition.; Results: Hyperglycemia, reduced glucose tolerance, dyslipidemia, and hepatic macrovesicles in high-fructose-diet-fed rats (4 weeks) confirmed the development of hepatosteatosis. Natural reversion in these parameters was observed upon shifting to normal diet in untreated control animals. Administration of VCO, however, increased this natural reversion by improving high-density lipoprotein cholesterol level (53.5%) and reducing hepatic and serum triacylglycerols (78.0 and 51.7%). Increased hepatic glutathione level (P < 0.01), antioxidant enzyme activities (P < 0.05) and reduced lipid peroxidation were also noticed in these animals. These observations were in concordance with reduced liver enzyme activities (P < 0.01) and restoration of altered hepatic architecture.; Conclusion: The study indicates that VCO can be used as a nutraceutical against hepatosteatosis. © 2017 Society of Chemical Industry.; © 2017 Society of Chemical Industry.
  • References (41)
  • Citations (8)
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References41
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#1Arunaksharan Narayanankutty (University of Calicut)H-Index: 7
#2Jeksy Jos Manalil (University of Calicut)H-Index: 4
Last. Achuthan C. Raghavamenon (University of Calicut)H-Index: 5
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Hepatosteatosis is a complex disorder, in which insulin resistance and associated dyslipidemic and inflammatory conditions are fundamental. Dietary habit, especially regular consumption of fat and sugar-rich diet, is an important risk factor. Coconut and mustard oils (CO and MO) are medium-chain saturated and monounsaturated fats that are common dietary ingredients among the Indian populations. Present study analyzed the effect of prolonged consumption of the fresh and thermally oxidized forms o...
6 CitationsSource
AbstractVirgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol content (VCOP), the mechanistic basis of which is less explored. Liquid chromatography/mass spectroscopy (LC/MS) analysis of VCOP ...
15 CitationsSource
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#1Arunaksharan Narayanankutty (University of Calicut)H-Index: 7
#2Anagha Kottekkat (University of Calicut)H-Index: 1
Last. Achuthan C. Raghavamenon (University of Calicut)H-Index: 5
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AbstractOmega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in ...
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Abstract Background The emerging health benefit of virgin coconut oil (VCO) has been associated with its potent natural antioxidants; however, the antioxidant and hepatoprotective effect of VCO against methotrexate-induced liver damage and oxidative stress remains unexplored. The study explored the antioxidant and hepatoprotective effects of VCO against oxidative stress and liver damage induced by anticancer drug methotrexate (MTX) in rats. Methods Liver damage was induced in Wistar rats pretrea...
15 CitationsSource
#1Devi Lekshmi Sheela (Kerala Agricultural University)H-Index: 1
#2Puthiyaveetil Abdulla Nazeem (Kerala Agricultural University)H-Index: 1
Last. Achuthan C. RaghavamenonH-Index: 5
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The coconut oil (CO) contains 91 % of saturated fatty acids in which 72 % are medium chain fatty acids (MCFAs) like lauric, capric and caprylic acids. In contrast to animal fat, coconut oil has no cholesterol. Despite this fact, CO is sidelined among other vegetable oils due to the health hazards attributed to the saturated fatty acids. Though various medicinal effects of CO have been reported including the hypolipidemic activity, people are still confused in the consumption of this natural oil....
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#1Ss Nair (University of Calicut)H-Index: 1
#2Jeksy Jos Manalil (University of Calicut)H-Index: 4
Last. Achuthan C. Raghavamenon (University of Calicut)H-Index: 5
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Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or...
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#1Ildefonso Rodríguez-Ramiro (UEA: University of East Anglia)H-Index: 10
#2David Vauzour (UEA: University of East Anglia)H-Index: 30
Last. Anne Marie Minihane (UEA: University of East Anglia)H-Index: 47
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Abstract Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of the metabolic syndrome and its prevalence is rapidly increasing due to its strong association with insulin resistance and obesity. At present, given that NAFLD is highly prevalent and therapies are limited, much attention is focused on identifying effective dietary strategies for the prevention and treatment of the disease. Polyphenols are a group of plant bioactive compounds whose regular consumption...
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#1Wale Johnson Adeyemi (Redeemer's University)H-Index: 2
#2La Olayaki (University of Ilorin)H-Index: 7
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Abstract In this study, we compared the anti-obesitogenic effects of virgin coconut oil (VCO), omega3 fatty acids (N-3), and orlistat in obese Wistar rats fed with normo- or hyper-lipidaemic diets. The eighty rats (n = 10) that were used for this study were divided into 8 groups. The results revealed that VCO, N-3, and orlistat showed comparable effects on lactate dehydrogenase, superoxide dismutase, c-reactive protein, gamma-glutamyltranspeptidase, alkaline phosphatase, aspartate aminotransfera...
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#1Arunaksharan Narayanankutty (St. Joseph's College, Bangalore)H-Index: 1
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#1Mengyao Zhao (ECUST: East China University of Science and Technology)H-Index: 1
#2Xin Shen (ECUST: East China University of Science and Technology)H-Index: 1
Last. Liming Zhao (ECUST: East China University of Science and Technology)H-Index: 7
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Abstract The effects of (GlcN)2-3 on the development of high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice and the potential structural-functional relationship between different singular degrees of polymerization (DPs) COSs and CD36 activity were investigated. (GlcN)2-3 was found to significantly inhibit the levels of triglyceride, low density lipid protein and total cholesterol in the serum and liver, thus reducing hepatic steatosis and, ultimately, altering lipid accumula...
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#1Dl Sheela (Kerala Agricultural University)H-Index: 1
#2Arunaksharan Narayanankutty (University of Calicut)H-Index: 7
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Coconut oil (CO) is enriched with medium chain saturated fatty acids like lauric acid (LA), capric acid and caprylic acid, which are known to have several health benefits. LA, the predominant fatty...
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#1Arunaksharan Narayanankutty (University of Calicut)H-Index: 7
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Last. Achuthan C. Raghavamenon (University of Calicut)H-Index: 5
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Abstract Thermal oxidation products of edible oils including aldehydes, peroxides and polymerized triglycerides formed during the cooking process are increasingly debated as contributory to chronic degenerative diseases. Depending on the oil used for cooking, the source of fatty acids and its oxidation products may vary and would have a differential influence on the physiological process. Coconut oil (CO) is a medium chain triglyceride-rich edible oil used in South India and other Asia Pacific c...
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#1Arunaksharan Narayanankutty (University of Calicut)H-Index: 7
#2Soorya Parathodi Illam (University of Calicut)H-Index: 4
Last. Achuthan C. Raghavamenon (University of Calicut)H-Index: 5
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Abstract Background Edible oils, preferably plant origin are rich sources of fatty acids and other lipophilic antioxidants to the body. Among these, oils derived from the coconut kernel (Cocos nucifera) are widely used in India and the Asia Pacific, which includes copra oil (CO), virgin coconut oil (VCO) and refined, bleached and deodorized (RBD) oil. Based on the mode of preparation, their composition and biological effects vary. Scope and approach This review compares the physicochemical and b...
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#2Abiola M. Folawiyo (Ebonyi State University)H-Index: 1
Last. Opeyemi A. Famurewa (University of Jos)H-Index: 1
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Abstract Background Methotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid agent whose efficacy is limited by marked organ toxicities associated with oxidative stress. The study investigated beneficial effect of virgin coconut oil (VCO) supplementation on MTX-induced oxidative stress and inflammation in rats. Methods Rats were divided into 4 groups (n = 6): Control, MTX (20 mg/kg bw), VCO (5%) + MTX and VCO (15%) + MTX. The pre-treatment with VCO for 14 days was followed by sin...
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#1Devi Lekshmi Sheela (Kerala Agricultural University)H-Index: 1
#2P. A. Nazeem (Kerala Agricultural University)H-Index: 3
Last. Achuthan C. Raghavamenon (Kerala Agricultural University)H-Index: 5
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Abstract Coconut oil (CO), the primary choice of cooking purposes in the south Asian countries, is rich in medium chain saturated fatty acids, especially lauric acid (50–52%). The oil has high medicinal use in Ayurvedic system and known to contain polyphenolic antioxidants. Studies have reported that CO improves insulin sensitivity and shows hypoglycemic effect. However, there is no information regarding its effect on chronic diabetic complications including retinopathy and nephropathy is availa...
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#1Sunil K. Panchal (University of Southern Queensland)H-Index: 17
#2Sharyn Carnahan (University of Southern Queensland)H-Index: 1
Last. Lindsay Brown (University of Southern Queensland)H-Index: 42
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Increasing prevalence of obesity and metabolic syndrome warrants identification of potential therapeutic options for intervention. This study tested commercially available Virgin Coconut Oil and Coconut Nourish, as coconuts are rich sources of lauric and myristic acids. Male Wistar rats were fed either corn starch diet (C); high-carbohydrate, high-fat diet (H); high-carbohydrate, high-virgin coconut oil diet (HV); or high-carbohydrate, high-coconut Nourish diet (HN) for 16 weeks. Metabolic, live...
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