Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

Published on Mar 1, 2018in Journal of the Science of Food and Agriculture2.42
· DOI :10.1002/jsfa.8650
Arunaksharan Narayanankutty6
Estimated H-index: 6
Devika Mukundan Palliyil1
Estimated H-index: 1
+ 1 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
Hepatosteatosis, a form of nonalcoholic fatty liver disease (NAFLD), is being increasingly recognized as a major health burden worldwide. Insulin resistance, dyslipidemia and imbalances in adipokine/cytokine interplay are reported to be involved in the onset and progression of this disease. Use of dietary nutraceuticals in prevention and treatment of NAFLD is emerging. Virgin coconut oil (VCO), a fermented product of fresh coconut kernel, has been shown to impede the development of hepatosteatosis in rats. This study analyzes the potential of VCO to reverse the already developed hepatosteatosis condition.; Results: Hyperglycemia, reduced glucose tolerance, dyslipidemia, and hepatic macrovesicles in high-fructose-diet-fed rats (4 weeks) confirmed the development of hepatosteatosis. Natural reversion in these parameters was observed upon shifting to normal diet in untreated control animals. Administration of VCO, however, increased this natural reversion by improving high-density lipoprotein cholesterol level (53.5%) and reducing hepatic and serum triacylglycerols (78.0 and 51.7%). Increased hepatic glutathione level (P < 0.01), antioxidant enzyme activities (P < 0.05) and reduced lipid peroxidation were also noticed in these animals. These observations were in concordance with reduced liver enzyme activities (P < 0.01) and restoration of altered hepatic architecture.; Conclusion: The study indicates that VCO can be used as a nutraceutical against hepatosteatosis. © 2017 Society of Chemical Industry.; © 2017 Society of Chemical Industry.
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#1Ildefonso Rodríguez-Ramiro (UEA: University of East Anglia)H-Index: 10
#2David Vauzour (UEA: University of East Anglia)H-Index: 29
Last.Anne Marie Minihane (UEA: University of East Anglia)H-Index: 44
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Cited By7
#1Mengyao Zhao (ECUST: East China University of Science and Technology)H-Index: 1
#2Xin Shen (ECUST: East China University of Science and Technology)
Last.Liming Zhao (ECUST: East China University of Science and Technology)H-Index: 5
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#1Sunil K. Panchal (University of Southern Queensland)H-Index: 17
#2Sharyn Carnahan (University of Southern Queensland)H-Index: 1
Last.Lindsay Brown (University of Southern Queensland)H-Index: 41
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View next paperVirgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats