Match!

Bicuspid aortic valve related aortopathy

Published on Jan 1, 2019in The Japanese Journal of Thoracic and Cardiovascular Surgery
· DOI :10.1007/s11748-017-0821-x
Sina Stock4
Estimated H-index: 4
,
Salah A Mohamed14
Estimated H-index: 14
,
Hh Sievers34
Estimated H-index: 34
Cite
Abstract
Bicuspid aortic valve related aortopathy is known to significantly increase the risk for catastrophic aortic events and, therefore, represents a considerable health burden. Albeit of ongoing research in this field including genetic, molecular, hemodynamic and morphologic aspects, bicuspid aortic valve related aortopathy still represents an imperfectly understood disorder. This lack in knowledge results in a lack of consistency considering different therapeutic approaches. Recent studies have provided new insights into the etiology and clinical impacts of bicuspid aortic valve related aortopathy in different clinical settings, leading to a growing body of opinion towards a more individualized surgical approach than currently provided by the guidelines. Especially valvular hemodynamics—stenosis and regurgitation—seem to have significant impact on the development of bicuspid aortic valve related aortopathy. In this context, there is evidence that regurgitation of bicuspid aortic valves is the more fatal pathomechanism. Furthermore, “age” represents an aspect that should be taken into account when deciding whether to replace the aorta or not, because the diameter depends mainly on a patients age. The same diameter of the aorta in a 70-year old and a 20-year old patient has to be interpreted differently and should, therefore, result in different therapeutic strategies.
  • References (80)
  • Citations (3)
Cite
References80
Newest
#1Jiao Jiao (UM: University of Michigan)H-Index: 5
#2Wei Xiong (UM: University of Michigan)H-Index: 2
Last.Bo Yang (UM: University of Michigan)H-Index: 11
view all 10 authors...
#1Jie Wu (HMU: Harbin Medical University)H-Index: 7
#2Hui-Fang Song (Shanxi Medical University)H-Index: 3
Last.Songbin Fu (HMU: Harbin Medical University)H-Index: 28
view all 10 authors...