Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Volume: 7, Issue: 1
Published: Sep 8, 2017
Abstract
Autophagy plays a critical role in the maintenance of cellular homeostasis by degrading proteins, lipids and organelles. Autophagy is activated in response to stress, but its regulation in the context of other stress response pathways, such as those mediated by heat shock factor 1 (HSF1) and nuclear factor-erythroid 2 p45-related factor 2 (NRF2), is not well understood. We found that the Michael acceptor bis (2-hydoxybenzylidene)acetone (HBB2),...
Paper Details
Title
Transcription factors NRF2 and HSF1 have opposing functions in autophagy
Published Date
Sep 8, 2017
Volume
7
Issue
1
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