ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma
Abstract
Autophagy mediates resistance to various anticancer agents. In melanoma, resistance to targeted therapy has been linked to expression of Wnt5A, an intrinsic inhibitor of β-catenin, which also promotes invasion. In this study, we assessed the interplay between Wnt5A and autophagy by combining expression studies in human clinical biopsies with functional analyses in cell lines and mouse models. Melanoma cells with high Wnt5A and low β-catenin...
Paper Details
Title
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma
Published Date
Oct 31, 2017
Journal
Volume
77
Issue
21
Pages
5873 - 5885
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History