scinapse is loading now...
  • References (1)
  • Citations (3)
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Cited By3
Published on Mar 7, 2019in Frontiers in Public Health
Gemma A. Bilkey1
Estimated H-index: 1
(Government of Western Australia),
Belinda L. Burns1
Estimated H-index: 1
(Government of Western Australia)
+ 3 AuthorsKristen J. Nowak26
Estimated H-index: 26
(University of Western Australia)
Advances in precision medicine have presented challenges to traditional public health decision-making paradigms. Historical methods of allocating healthcare funds based on safety, efficacy, and efficiency, are challenged in a healthcare delivery model that focuses on individualised variations in pathology that form the core of precision medicine. Public health policy and decision-making must adapt to this new frontier of healthcare delivery to ensure that the broad public health goals of reducin...
1 Citations Source Cite
Published on Dec 1, 2018in Seminars in Perinatology 2.88
Fani Memi4
Estimated H-index: 4
(University College London),
Aglaia Ntokou1
Estimated H-index: 1
(Yale University),
Irinna Papangeli7
Estimated H-index: 7
(Yale University)
Abstract Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing technology has armed researchers with a revolutionary tool for gene therapy. However, as the breadth of research and clinical applications of this technology continues to expand, outstanding technical challenges and ethical considerations wi...
Source Cite
Published on Aug 1, 2018in Journal of Assisted Reproduction and Genetics 2.79
A. Hershlag2
Estimated H-index: 2
(Hofstra University),
S.L. Bristow1
Estimated H-index: 1
(Hofstra University)
The rapid development of gene-editing technologies has led to an exponential rise in both basic and translational research initiatives studying molecular processes and investigating possible clinical applications. Early experiments using genome editing to study human embryo development have contradicted findings in studies on model organisms. Additionally, a series of four experiments over the past 2 years set out to investigate the possibilities of introducing genetic modifications to human emb...
1 Citations Source Cite