• References (1)
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Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
Genome editing could be applied to correct disease-causing mutations in human embryos, but concerns about efficacy and safety are paramount. Shoukhrat Mitalipov and colleagues use CRISPRCas9 to correct a heritable cardiomyopathy mutation in human embryos. By optimizing the experimental conditions, the authors show very reduced mosaicism, and report that for this heterozygous mutation, CRISPRCas9-induced breaks seem to be preferentially repaired using the wild-type allele as a template in human e...
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  • Citations (3)
Cited By3
Published on Aug 1, 2018in Journal of Assisted Reproduction and Genetics 2.79
A. Hershlag2
Estimated H-index: 2
(Hofstra University),
Sara L. Bristow1
Estimated H-index: 1
(Hofstra University)
The rapid development of gene-editing technologies has led to an exponential rise in both basic and translational research initiatives studying molecular processes and investigating possible clinical applications. Early experiments using genome editing to study human embryo development have contradicted findings in studies on model organisms. Additionally, a series of four experiments over the past 2 years set out to investigate the possibilities of introducing genetic modifications to human emb...
1 Citations Source Cite
Published on Dec 1, 2018in Seminars in Perinatology 2.88
Fani Memi4
Estimated H-index: 4
(University College London),
Aglaia Ntokou1
Estimated H-index: 1
(Yale University),
Irinna Papangeli7
Estimated H-index: 7
(Yale University)
Abstract Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing technology has armed researchers with a revolutionary tool for gene therapy. However, as the breadth of research and clinical applications of this technology continues to expand, outstanding technical challenges and ethical considerations wi...
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Published on Mar 7, 2019in Frontiers in Public Health
Gemma A. Bilkey1
Estimated H-index: 1
Belinda L. Burns1
Estimated H-index: 1
+ 3 AuthorsKristen J. Nowak26
Estimated H-index: 26
1 Citations Source Cite