An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD
Abstract
Key Points NOTCH2 activation confers a marked increase in BCR responsiveness by cGVHD patient B cells that associates with increased BLNK. ATRA increases the IRF4-to-IRF8 ratio and blocks aberrant NOTCH2-BCR activation without affecting cGVHD patient B-cell...
Paper Details
Title
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD
Published Date
Nov 9, 2017
Journal
Volume
130
Issue
19
Pages
2131 - 2145
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Notes
History