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Y Chromosome Missing Protein, TBL1Y, May Play an Important Role in Cardiac Differentiation

Published on Dec 1, 2017in Journal of Proteome Research3.78
· DOI :10.1021/acs.jproteome.7b00391
Anna Meyfour2
Estimated H-index: 2
,
Hassan Ansari4
Estimated H-index: 4
+ 5 AuthorsGhasem Hosseini Salekdeh36
Estimated H-index: 36
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Abstract
Despite evidence for sex-specific cardiovascular physiology and pathophysiology, the biological basis for this dimorphism remains to be explored. Apart from hormonal factors, gender-related characteristics may reside in the function of sex chromosomes during cardiac development. In this study, we investigated the differential expression of the male-specific region of the Y chromosome (MSY) genes and their X counterparts during cardiac differentiation of human embryonic stem cells (hESC). We observed alterations in mRNA and protein levels of TBL1Y, PCDH11Y, ZFY, KDM5D, USP9Y, RPS4Y1, DDX3Y, PRY, XKRY, BCORP1, RBMY, HSFY, and UTY, which accompanied changes in intracellular localization. Of them, the abundance of a Y chromosome missing protein, TBL1Y, showed a significant increase during differentiation while the expression level of its X counterpart decreased. Consistently, reducing TBL1Y cellular level using siRNA approach influenced cardiac differentiation by reducing its efficacy as well as increasing th...
  • References (51)
  • Citations (6)
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References51
Newest
#1Gaetano D'Amato (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 8
#2Guillermo Luxán (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 9
Last.José Luis de la Pompa (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 40
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#1Gaetano D'Amato (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 8
#2Guillermo Luxán (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 9
Last.Fernando Martínez (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 4
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#1Hananeh Fonoudi (VCCRI: Victor Chang Cardiac Research Institute)H-Index: 4
#2Hassan Ansari (Academic Center for Education, Culture and Research)H-Index: 4
Last.Sara Pahlavan (Academic Center for Education, Culture and Research)H-Index: 6
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#1Xin Zhu (CSU: Central South University)H-Index: 5
#2Furong Dai (CSU: Central South University)H-Index: 4
Last.Yi Zhang (CSU: Central South University)H-Index: 5
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#1Louise J. Walport (University of Oxford)H-Index: 14
#2Richard J. Hopkinson (University of Oxford)H-Index: 18
Last.C. Johansson (SGC: Structural Genomics Consortium)H-Index: 16
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Cited By6
Newest
#1José González-Gomariz (University of Navarra)
#2Elizabeth Guruceaga (University of Navarra)H-Index: 13
Last.Victor Segura (University of Navarra)H-Index: 24
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#1Stacy Colaco (National Institute for Research in Reproductive Health)H-Index: 2
#2Deepak Modi (National Institute for Research in Reproductive Health)H-Index: 22
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