A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function
Abstract
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet...
Paper Details
Title
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function
Published Date
Sep 1, 2017
Journal
Volume
26
Issue
3
Pages
475 - 492.e7
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