THU0044 Chondroitin sulphate inhibits monocyte chemoattractant protein-1 release from 3T3L1 adipocytes: a new treatment opportunity for obesity-related metabolic syndromes?

Background

Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. We have recently published that chondroitin sulphate (CS) can attenuate the monosodium urate (MSU) crystal mediated THP-1 macrophage inflammatory response reflected by reduced release of pro-inflammatory cytokines IL-1β and TNFα. We have also recently determined that the CS...