Targeting cellular senescence prevents age-related bone loss in mice
Abstract
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC 'suicide' transgene encoding an inducible caspase 8 expressed specifically in senescent cells) or pharmacological (i.e., 'senolytic' compounds) means...
Paper Details
Title
Targeting cellular senescence prevents age-related bone loss in mice
Published Date
Sep 1, 2017
Journal
Volume
23
Issue
9
Pages
1072 - 1079
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