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Safe-by-Design: from Safety to Responsibility

Published on Dec 1, 2017in Nanoethics1.359
· DOI :10.1007/s11569-017-0301-x
Ibo van de Poel23
Estimated H-index: 23
(TU Delft: Delft University of Technology),
Zoë Robaey4
Estimated H-index: 4
(TU Delft: Delft University of Technology)
Abstract
Safe-by-design (SbD) aims at addressing safety issues already during the RD it also misses out on the resources that users (and others) can bring for achieving safety, and it is undemocratic. We argue that rather than directly designing for safety, it is better to design for the responsibility for safety, i.e., designers should think where the responsibility for safety is best situated and design technologies accordingly. We propose some heuristics that can be used in deciding how to share and distribute responsibility for safety through design.
  • References (27)
  • Citations (8)
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References27
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#1Rune Hjorth (DTU: Technical University of Denmark)H-Index: 9
#2Lilian van HoveH-Index: 4
Last. Fern WicksonH-Index: 17
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Abstract“Safety by design” (SbD) is an intuitively appealing concept that is on the rise within nanotoxicology and nanosafety research, as well as within nanotechnology research policy. It leans on principles established within drug discovery and development (DDD) and seeks to address safety early, as well as throughout product development. However, it remains unclear what the concept of SbD exactly entails for engineered nanomaterials (ENMs) or how it is envisioned to be implemented. Here, we r...
12 CitationsSource
#1Zoë Robaey (TU Delft: Delft University of Technology)H-Index: 4
The use of genetically modified organisms in agriculture makes great promises of better seeds, but also raises many controversies about ownership of seeds and about potential hazards. I suggest that owners of these seeds bear the responsibility to do no harm in using these seeds. After defining the nature of this responsibility, this paper asks, if ownership entails moral responsibility, and ownership can be transferred, then how is moral responsibility transferred? Building on the literature on...
3 CitationsSource
#1Ibo van de Poel (TU Delft: Delft University of Technology)H-Index: 23
How are we to appraise new technological developments that may bring revolutionary social changes? Currently this is often done by trying to predict or anticipate social consequences and to use these as a basis for moral and regulatory appraisal. Such an approach can, however, not deal with the uncertainties and unknowns that are inherent in social changes induced by technological development. An alternative approach is proposed that conceives of the introduction of new technologies into society...
19 CitationsSource
#1Zoë Robaey (TU Delft: Delft University of Technology)H-Index: 4
Genetically modified organisms are a technology now used with increasing frequency in agriculture. Genetically modified seeds have the special characteristic of being living artefacts that can reproduce and spread; thus it is difficult to control where they end up. In addition, genetically modified seeds may also bring about uncertainties for environmental and human health. Where they will go and what effect they will have is therefore very hard to predict: this creates a puzzle for regulators. ...
10 CitationsSource
Tim Trevan calls on those working with organisms that are hazardous, or could be so, to take lessons from the nuclear industries, hospitals and other sectors that have established a safety culture.
5 CitationsSource
In this paper, we present two different approaches to responsible research and innovation in synthetic biology. By combining these approaches, we aim to facilitate a process of mutual learning, involving young students involved in the international Genetically Engineered Machines (iGEM) competition, researchers from the field and a variety of societal stakeholders in the governance of synthetic biology innovation.
9 CitationsSource
#1Ajk Auke PolsH-Index: 5
#2A Andreas SpahnH-Index: 4
In this chapter, we provide an overview of literature on the relation between technology and design and the values of democracy and justice. We first explore how philosophy has traditionally conceptualized democracy and justice. We then examine general philosophical theories and arguments about this relation, dealing with the conception of technology as being "value-free" as well as with pessimistic and more optimistic assessments with regard to technology’s potential for advancing democracy and...
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#1Auke PolsH-Index: 1
#2Andreas SpahnH-Index: 1
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#2Neelke DoornH-Index: 13
Last. Ibo van de PoelH-Index: 23
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#1Oliver Wright (Imperial College London)H-Index: 2
#2Guy-Bart Stan (Imperial College London)H-Index: 29
Last. Tom Ellis (Imperial College London)H-Index: 22
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As the field of synthetic biology develops, real-world applications are moving from the realms of ideas and laboratory-confined research towards implementation. A pressing concern, particularly with microbial systems, is that self-replicating re-engineered cells may produce undesired consequences if they escape or overwhelm their intended environment. To address this biosafety issue, multiple mechanisms for constraining microbial replication and horizontal gene transfer have been proposed. These...
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#1Enrique Asin-Garcia (WUR: Wageningen University and Research Centre)
#2Amalia Kallergi (Radboud University Nijmegen)
Last. Vitor A. P. Martins dos Santos (WUR: Wageningen University and Research Centre)H-Index: 31
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Safety-by-design (SbD) is paramount for risk management in synthetic biology, with genetic safeguards being a key technology for its implementation. While attractive in theory, the integration of genetic safeguards into SbD strategies is rarely exercised in practice, despite technological advances. Here we question why and what might be done about it.
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#1Aron J. Huckaba (Wallis)H-Index: 13
#2Daniel T. Sun (Wallis)
Last. Mohammad Khaja Nazeeruddin (Wallis)H-Index: 104
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#1Melanie Schmutz (HSG: University of St. Gallen)
#1Mélanie SchmutzH-Index: 1
Last. Claudia SomH-Index: 16
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Safe-by-Design (SbD) concepts foresee the risk identification and reduction as well as uncertainties regarding human health and environmental safety in early stages of product development. The EU's NANoREG project and further on the H2020 ProSafe initiative, NanoReg2, and CALIBRATE projects have developed a general SbD approach for nanotechnologies (e.g., paints, textiles, etc.). Based on it, the GoNanoBioMat project elaborated a methodological SbD approach (GoNanoBioMat SbD approach) for nanome...
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#1Shiko M. Ben-Menahem (ETH Zurich)H-Index: 3
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Abstract Silver nanoparticles (AgNPs) represent one of the most abundant biocidal nanomaterials contained in more than 30% of nano-enabled consumer products and 75% of nanomedical products. The cumulative exposure of the general population may therefore reach critical and potentially hazardous levels. Due to data gaps on AgNP effects in humans, it is urgent to further evaluate their possible toxicity, particularly in vulnerable systems like the nervous one. As AgNPs may cross the blood brain and...
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#1Anjan Chamuah (JNU: Jawaharlal Nehru University)H-Index: 1
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#1Stephanie J. Bird (MIT: Massachusetts Institute of Technology)H-Index: 9
Humans are powerful and clever, and also more ignorant than they know. As a result, they too often fail to acknowledge or even recognize their limitations, and are more arrogant than humble regarding their capabilities. Education that explicitly recognizes and addresses the context of science and technology, their inherent values and ethical implications and concerns, and their problematic as well as beneficial impacts can potentially rescue the human species from itself.
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The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D-printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. First, the applicability of FFF in lab-on-a-chip device development is briefly discussed. Subsequently, a methodology to categorize, identify and implement SbD measures for FFF is suggested. Furthermore, the most crucial health risks involved in FFF processes are examined, placing the focus on the examination of u...
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#1Osiris A. Valdez Banda (Aalto University)H-Index: 6
#2Sirpa KannosH-Index: 1
Last. Pentti Kujala (Aalto University)H-Index: 27
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Abstract Autonomous vessels have become a topic of high interest for the maritime transport industry. Recent progress in the development of technologies enabling autonomous systems has fostered the idea that autonomous vessels will soon be a reality. However, before the first autonomous vessel can be released into her actual context of operation, it is necessary to ensure that it is safe. This is a major challenge as the experience of autonomous ships is very limited. This study highlights the n...
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