Modelling multi-site transmission of the human papillomavirus and its impact on vaccination effectiveness

Previous HPV models have only included genital transmission, when evidence suggests that transmission between several anatomical sites occurs. We compared model predictions of population-level HPV vaccination effectiveness against genital HPV16 infection in women, using a 1) uni-site (genital site), and a 2) multi-site model (genital and one extragenital site).We developed a uni-site and a multi-site deterministic HPV transmission model,...