Investigation of cardiac fibroblasts using myocardial slices
Abstract
Aims Cardiac fibroblasts (CFs) are considered the principal regulators of cardiac fibrosis. Factors that influence CF activity are difficult to determine. When isolated and cultured in vitro, CFs undergo rapid phenotypic changes including increased expression of α-SMA. Here we describe a new model to study CFs and their response to pharmacological and mechanical stimuli using in vitro cultured mouse, dog and human myocardial slices. Methods and...
Paper Details
Title
Investigation of cardiac fibroblasts using myocardial slices
Published Date
Aug 18, 2017
Journal
Volume
114
Issue
1
Pages
77 - 89
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