In Situ Capture of Chromatin Interactions by Biotinylated dCas9
Abstract
Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features, yet the molecular composition of the vast majority of CREs in chromatin remains unknown. Here, we describe a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly identify locus-specific chromatin-regulating protein complexes and long-range DNA interactions. Using an in vivo biotinylated nuclease-deficient Cas9 protein...
Paper Details
Title
In Situ Capture of Chromatin Interactions by Biotinylated dCas9
Published Date
Aug 1, 2017
Journal
Volume
170
Issue
5
Pages
1028 - 1043.e19
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