Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.
Abstract
N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA metabolism, regulating biological processes including stem cell pluripotency, cell differentiation, and energy homeostasis. m6A is recognized by selective binding proteins; YTHDF1 and YTHDF3 work in concert to affect the translation of m6A-containing mRNAs, YTHDF2 expedites mRNA decay, and...
Paper Details
Title
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.
Published Date
Aug 15, 2017
Journal
Volume
27
Issue
9
Pages
1115 - 1127
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History