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Using murine colitis models to analyze probiotics-host interactions.

Published on Aug 1, 2017in Fems Microbiology Reviews11.524
· DOI :10.1093/femsre/fux035
Rebeca Martín22
Estimated H-index: 22
(Université Paris-Saclay),
Florian Chain17
Estimated H-index: 17
(Université Paris-Saclay)
+ 4 AuthorsPhilippe Langella57
Estimated H-index: 57
(Université Paris-Saclay)
Abstract
  • References (225)
  • Citations (8)
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Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F. prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. This current paper we tested MAM effect on NF-κB pa...
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