Using murine colitis models to analyze probiotics-host interactions.

Published on Aug 1, 2017in Fems Microbiology Reviews11.524
· DOI :10.1093/femsre/fux035
Rebeca Martín22
Estimated H-index: 22
(Université Paris-Saclay),
Florian Chain17
Estimated H-index: 17
(Université Paris-Saclay)
+ 4 AuthorsPhilippe Langella57
Estimated H-index: 57
(Université Paris-Saclay)
  • References (225)
  • Citations (8)
📖 Papers frequently viewed together
35 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Harry SokolH-Index: 48
#2Valentin Leducq (University of Paris)H-Index: 3
Last. Laurent BeaugerieH-Index: 53
view all 16 authors...
The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce. The aim of our study was to characterise the faecal fungal microbiota in patients with IBD. Bacterial and fungal composition of the faecal microbiota of 235 patients with IBD and 38 healthy subjects (HS) was determined using 16S and ITS2 sequencing, respectively. The obtained sequences were analysed usin...
211 CitationsSource
#1Imen Trabelsi (University of Sfax)H-Index: 5
#2Naourez Ktari (University of Sfax)H-Index: 16
Last. R. Ben Salah (University of Sfax)H-Index: 1
view all 5 authors...
This study aimed to investigate the potential effects of an oral treatment by a newly isolated probiotic Lactobacillus plantarum TN8 strain on trinitrobenzene sulphonic acid (TNBS)-induced colitis in Wistar rats. Thus, 18 rats were divided into three groups (n = 6 per group): group 1 (control) - rats not receiving TNBS application; group 2 - rats receiving an intrarectal TNBS infusion (100 mg/kg TNBS dissolved in ethanol); and group 3 - rats treated with intragastrical TN8 strain once per day (f...
4 CitationsSource
#1Sayaka NagataH-Index: 14
#2Motoo YamasakiH-Index: 3
Last. Kazuo KitamuraH-Index: 58
view all 3 authors...
Preclinical Research Human adrenomedullin (hAM), a hypotensive peptide, also has anti-inflammatory effects. hAM can reduce the severity of the dextran sulphate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in animal models. Furthermore, in a clinical study, hAM treatment reduced the Disease Activity Index in ulcerative colitis. However, these therapeutic effects required continuous administration of hAM as the half-life of native hAM is quite short in blood. To res...
10 CitationsSource
#1V. Lorén (Ciber)H-Index: 3
#2J. Manyé (Ciber)H-Index: 4
Last. Jordi Espadaler (Autonomous University of Barcelona)H-Index: 13
view all 6 authors...
Use of probiotic therapy is an active area of investigation to treat intestinal disorders. The clinical benefits of the I3.1 probiotic formula (Lactobacillus plantarum (CECT7484, CECT7485) and P. acidilactici (CECT7483)) were demonstrated in irritable bowel syndrome (IBS) patients in a randomized, double-blind, placebo-controlled clinical trial. The aim of this study was to evaluate the therapeutic effects of I3.1 in two experimental models of colitis, a dextran sulfate sodium (DSS)-induced coli...
7 CitationsSource
#1Natalia M. Breyner (INRA: Institut national de la recherche agronomique)H-Index: 1
#2Cristophe Michon (INRA: Institut national de la recherche agronomique)H-Index: 1
Last. Jean M. Chatel (INRA: Institut national de la recherche agronomique)H-Index: 3
view all 8 authors...
Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F. prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. This current paper we tested MAM effect on NF-κB pa...
31 CitationsSource
#1Matthieu Galtier (Pasteur Institute)H-Index: 3
#2Luisa De Sordi (Pasteur Institute)H-Index: 5
Last. Laurent Debarbieux (Pasteur Institute)H-Index: 25
view all 12 authors...
Background and Aims Adherent invasive Escherichia coli (AIEC) are abnormally predominant on the ileal mucosa of Crohn’s disease (CD) patients. They bind to the CEACAM6 receptor expressed on the surface of epithelial cells. We aimed to assess the potential of bacteriophages, viruses infecting bacteria, to decrease the levels of AIEC bacteria associated with the intestinal mucosa. Methods We combined ex vivo and in vivo experiments with murine and human intestinal samples to quantify the ability o...
26 CitationsSource
#1Shaik Abdul Hussain (NDRI: National Dairy Research Institute)H-Index: 6
#2G. R. Patil (NDRI: National Dairy Research Institute)H-Index: 10
Last. Suman Kapila (NDRI: National Dairy Research Institute)H-Index: 18
view all 7 authors...
Abstract The aim of present work was to investigate preventive role of orally administered Aloe vera supplemented probiotic lassi (APL) on Shigella dysenteriae infection in mice. At the end of experimental period (2, 5 and 7 days of challenging), different organs such as spleen, liver, small intestine, large intestine, and peritoneal fluid were collected and assessed for Shigella colonization. Secretary IgA was estimated in intestinal fluid. Blood was collected in heparinized tubes for various h...
9 CitationsSource
#1Su-Hyeon Eun (Kyung Hee University)H-Index: 4
#2Su-Min Lim (Kyung Hee University)H-Index: 10
Last. D.-H. Kim (Kyung Hee University)H-Index: 61
view all 5 authors...
AbstractTo understand the anti-colitic effects of probiotics that up-regulate interleukin (IL)-10 expression in dendritic cells (DCs) and macrophages, we isolated Lactobacillus sakei K17, which potently induced IL-10 expression in DCs and peritoneal macrophages in vitro, among the lactic acid bacteria strains collected from kimchi and investigated its anti-inflammatory effect in mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Oral administration of K17 (2 × 109 CFU·mouse−1·...
8 CitationsSource
#1Jennifer K. Spinler (BCM: Baylor College of Medicine)H-Index: 13
#2Cana Ross (BCM: Baylor College of Medicine)H-Index: 4
Last. Tor C. Savidge (BCM: Baylor College of Medicine)H-Index: 37
view all 3 authors...
Abstract With the end of the golden era of antibiotic discovery, the emergence of a new post-antibiotic age threatens to thrust global health and modern medicine back to the pre-antibiotic era. Antibiotic overuse has resulted in the natural evolution and selection of multi-drug resistant bacteria. One major public health threat, Clostridium difficile, is now the single leading cause of hospital-acquired bacterial infections and is by far the most deadly enteric pathogen for the U.S. population. ...
20 CitationsSource
#1Carlos Gómez-Gallego (UTU: University of Turku)H-Index: 9
#2S. Pohl (University of Vienna)H-Index: 1
Last. Wolfgang Kneifel (University of Vienna)H-Index: 34
view all 5 authors...
Akkermansia muciniphila is an intestinal anaerobe which has been proposed as a new functional microbe with probiotic properties. However, the species is not included in the European Union qualified presumption of safety (QPS) list and has not yet been assessed. Moreover, products containing A. muciniphila are not on the market and are thus controlled by the Novel Foods Regulation, which requires extensive safety assessment. This review addresses the safety aspects of the use of A. muciniphila ba...
34 CitationsSource
Cited By8
#1Jun Ke (HUST: Huazhong University of Science and Technology)
#2Ying Li (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Xiaohua Hou (HUST: Huazhong University of Science and Technology)H-Index: 25
view all 7 authors...
#1Sujuan Ding (HAU: Hunan Agricultural University)H-Index: 4
#2Yong Ma (HAU: Hunan Agricultural University)H-Index: 3
Last. Jun Fang (HAU: Hunan Agricultural University)H-Index: 12
view all 6 authors...
The aim of this study was to examine the effects of Lactobacillus brevis on the microbial community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR mice were randomly distributed into three treatment groups: (i) Lactobacillus brevis treatment alone (control), (ii) DSS administration alone, and (iii) treatment with Lactobacillus brevis and DSS. Our results demonstrate that Lactobacillus brevis treatment significantly alleviated DSS-induced body weight loss and colon i...
#1Unai Escribano-Vazquez (Université Paris-Saclay)H-Index: 1
#2Sophie Verstraeten (Université Paris-Saclay)
Last. Claire Cherbuy (Université Paris-Saclay)H-Index: 19
view all 7 authors...
Escherichia coli is a regular inhabitant of the gut microbiota throughout life. However, its role in gut health is controversial. Here, we investigated the relationship between the commensal E. coli strain CEC15 (CEC), which we previously isolated, and the intestine in homeostatic and disease-prone settings. The impact of CEC was compared to that of the probiotic E. coli Nissle 1917 (Nissle) strain. The expression of ileal and colonic genes that play a key role in intestinal homeostasis was high...
#1Naoko Hattori (Epigenomics AG)H-Index: 11
#2Tohru Niwa (Epigenomics AG)H-Index: 20
Last. Toshikazu Ushijima (Epigenomics AG)H-Index: 57
view all 10 authors...
2 CitationsSource
Inflammatory bowel disease is triggered by an uncontrolled immune response associated with genetic, environmental, and intestinal microbiota imbalance. Ipomoea asarifolia (IA), popularly known as “salsa” or “brave salsa”, belongs to the Convolvulaceae family. The aim of this approach was to study the preventive effect of IA aqueous extract in 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rats. Rats pretreated with IA extract or sulfasalazine (SSZ) received intracolonic instillation ...
1 CitationsSource
#1Ashish K. Singh (UCD: University College Dublin)H-Index: 1
#2Rosanne Y. Hertzberger (UvA: University of Amsterdam)H-Index: 4
Last. Ulla G. Knaus (UCD: University College Dublin)H-Index: 49
view all 3 authors...
Abstract Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease of the gastrointestinal tract, characterized by cycles of acute flares, recovery and remission phases. Treatments for accelerating tissue restitution and prolonging remission are scarce, but altering the microbiota composition to promote intestinal homeostasis is considered a safe, economic and promising approach. Although probiotic bacteria have not yet fulfilled fully their promise in clinical trials, un...
3 CitationsSource
#1Monica Barone (UNIBO: University of Bologna)H-Index: 3
#2Florian Chain (Université Paris-Saclay)H-Index: 17
Last. Rebeca Martín (Université Paris-Saclay)H-Index: 22
view all 7 authors...
Murine colitis models are crucial tools for understanding intestinal homeostasis and inflammation. However, most current models utilize a highly inbred strain of mice, and often only one sex is employed to limit bias. This targeted approach, which in itself is biased, means that murine genetic diversity and sex-related differences are ignored, making it even more difficult to extend findings to humans, who are highly heterogeneous. Furthermore, most models do not examine the chronic form of coli...
2 CitationsSource