Pleiotropic Effects of Schizophrenia And Cognitive LOCI: A Meta-Analytic Approach

Cognitive deficits are a key feature of schizophrenia. The genetic architecture underlying cognition is investigated. A novel method of using cross-phenotype meta-analysis to elucidate overlapping genetic substrates between established schizophrenia loci and cognitive loci was conducted. 895 healthy controls and 648 schizophrenia subjects with intact cognitive data were included in the discovery dataset after standard genome-wide QC procedures....