Oxygen availability and metabolic reprogramming in cancer

Volume: 292, Issue: 41, Pages: 16825 - 16832
Published: Oct 13, 2017
Abstract
Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer cells adapt to low O2 has been illuminated by numerous studies, with reprogrammed metabolism being one of the most important mechanisms. This metabolic reprogramming not only promotes cancer cell plasticity, but also provides novel insights for treatment strategies. As the most studied O2 sensor, hypoxia-inducible factor (HIF) is regarded as an important...
Paper Details
Title
Oxygen availability and metabolic reprogramming in cancer
Published Date
Oct 13, 2017
Volume
292
Issue
41
Pages
16825 - 16832
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