Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Pages: 179622
Published: Aug 22, 2017
Abstract
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e. the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally-arising heteroplasmy have not been experimentally studied to date. We hence generated a conplastic mouse strain...
Paper Details
Title
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice
Published Date
Aug 22, 2017
Journal
Pages
179622
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