Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements
Abstract
The challenge of linking intergenic mutations to target genes has limited molecular understanding of diverse human diseases. Here, we show H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells. Differentiation of naive T cells to either T helper 17 cells or regulatory T cells create subtype-specific enhancer-promoter interactions,...
Paper Details
Title
Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements
Published Date
Aug 26, 2017
Journal
Pages
178269
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