Integrins as Therapeutic Targets: Successes and Cancers
Abstract
Integrins are transmembrane receptors that are central to the biology of many human pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with an emerging role as local activators of TGFβ, they influence cancer, fibrosis, thrombosis and inflammation. Their ligand binding and some regulatory sites are extracellular and sensitive to pharmacological intervention, as proven by the clinical success of seven drugs...
Paper Details
Title
Integrins as Therapeutic Targets: Successes and Cancers
Published Date
Aug 23, 2017
Journal
Volume
9
Issue
9
Pages
110
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Notes
History