Biochemical Studies on IGF and IGF-Binding Proteins Interactions & Structural Investigations on the SH3 Domain of Crk-associated Tyrosine Kinase Substrate p130cas (CAS)
Published: Jan 1, 2005
Abstract
In my work, I have undertaken the thorough biochemical and biostructural studies of insulin-like growth factor binding proteins (IGFBPs), and the SH3 domain of Crk-associated substrate p130cas (CAS). Based on NMR and crystal structures of mini-IGFBP-5, mutants were designed investigate binding interactions between IGF and IGFBP-5. Kinetic analysis using surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) showed the degree...
Paper Details
Title
Biochemical Studies on IGF and IGF-Binding Proteins Interactions & Structural Investigations on the SH3 Domain of Crk-associated Tyrosine Kinase Substrate p130cas (CAS)
Published Date
Jan 1, 2005
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