A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch
Abstract
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and inflammation. Profiling of tissue-specific precursor abundance and biosynthetic gene expression predicted that inflamed skin would be abundant in four previously unknown 11-hydroxy-epoxy- or...
Paper Details
Title
A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch
Published Date
Aug 22, 2017
Journal
Volume
10
Issue
493
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