Differential spectrum approach to uncovering the electroencephalographic signatures of the opponent driving forces for sleep and wake underlying alternations of sleep and wake states

The opponent model of sleep-wake regulation postulated two opposing drives for sleep and wake. Simple measurement of slow wave activity does not allow their separation in the electroencephalographic (EEG) signal. However, we previously showed that scores on the 1st and 2nd principal components of variation in the EEG power spectrum can serve as markers of the opposing sleep and wake drives, respectively. The major purpose of the present report...