Early cytoplasmic uncoating is associated with infectivity of HIV-1

Volume: 114, Issue: 34, Pages: 201706245
Published: Aug 22, 2017
Abstract
After fusion, HIV delivers its conical capsid into the cytoplasm. To release the contained reverse-transcribing viral genome, the capsid must disassemble in a process termed uncoating. Defining the kinetics, dynamics, and cellular location of uncoating of virions leading to infection has been confounded by defective, noninfectious particles and the stochastic minefield blocking access to host DNA. We used live-cell fluorescent imaging of...
Paper Details
Title
Early cytoplasmic uncoating is associated with infectivity of HIV-1
Published Date
Aug 22, 2017
Volume
114
Issue
34
Pages
201706245
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