Correlation between diffusion tensor imaging and histological brain injury in ventilated preterm lambs

Objective: Inflammation and mechanical ventilation contribute additively to white matter injury in the preterm infant. We examined whether in vivo diffusion tensor imaging (DTI) indices correlate with immunohistochemical analyses of brain inflammation and injury caused by injurious ventilation at birth, in the presence or absence of intrauterine inflammation. Methods: Twin-bearing ewes received an ultrasound guided injection of...