Original paper
Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity
Abstract
Introduction Chronic low‐grade inflammation is associated with obesity and diabetes. However, what causes and mediates chronic inflammation in metabolic disorders is not well understood. Toll‐like receptor 4 (TLR4) mediates both infection‐induced and sterile inflammation by recognizing pathogen‐associated molecular patterns and endogenous molecules, respectively. Saturated fatty acids can activate TLR4, and TLR4‐deficient mice were protected...
Paper Details
Title
Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity
Published Date
Aug 4, 2017
Volume
5
Issue
4
Pages
526 - 540
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Notes
History