New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?
Abstract
The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple mechanisms through which non-germline encoded sequences can give rise to these non-conventional epitopes which in turn engage the...
Paper Details
Title
New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?
Published Date
Nov 1, 2017
Journal
Volume
84
Pages
12 - 20
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Notes
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