Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity
Abstract
Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of...
Paper Details
Title
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity
Published Date
Aug 11, 2017
Journal
Volume
6
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