Raman optical activity of human α‐synuclein in intrinsically disordered, micelle‐bound α‐helical, molten globule and oligomeric β‐sheet state

Alpha‐synuclein ( α ‐syn) is a 140 residue protein that plays a central role in Parkinson's disease and other neurological disorders. The precise function and pathological properties of α ‐syn remain however poorly understood. While α ‐syn is considered to be a flexible and disordered protein under native conditions, its ability to adopt a variety of conformational ensembles depending on the environment is considered to be related to its...