Estimating Population-Level Prevalence of Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy

Introduction: Transthyretin amyloidosis (ATTR) is found in both mutated (ATTRmt) and wild-type (ATTRwt) forms. Both forms are associated with increased risk of developing cardiomyopathy (CM) due to infiltration of the heart by amyloid fibrils, which causes diastolic dysfunction and heart failure. Furthermore, ATTRmt variants can manifest as either an exclusively CM phenotype or a mixed phenotype with CM and polyneuropathy (PN). Despite its role...