Polygenic hyperlipidemia and coronary artery disease risk

Aim: Hyperlipidemia, particularly elevated LDL-C, is an established and treatable risk factor for CAD. In addition to well-known FH mutations, hyperlipidemias have also been shown to be highly polygenic. Whereas monogenic FH elevates CAD risk considerably, it is unclear whether high polygenic LDL-C or TG burden causes similarly elevated CAD risk in a familial or population...