Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy
Abstract
Methods have been developed for Mendelian randomization that can obtain consistent causal estimates while relaxing the instrumental variable assumptions. These include multivariable Mendelian randomization, in which a genetic variant may be associated with multiple risk factors so long as any association with the outcome is via the measured risk factors (measured pleiotropy), and the MR‐Egger (Mendelian randomization‐Egger) method, in which a...
Paper Details
Title
Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy
Published Date
Sep 27, 2017
Journal
Volume
36
Issue
29
Pages
4705 - 4718
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