EPA + DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double‐blind, controlled study

Sustained high levels of activated polymorphonuclear leukocytes (PMNs) and PMN‐derived proteases in the microenvironment of chronic venous leg ulcers (CVLUs) are linked to chronic inflammation and delayed healing. Uncontrolled PMN activity eventually destroys newly developed tissue and degrades critical growth factors. The bioactive components of fish oil (n‐3 eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have strong...