Abstract 5255: Comparison of high-fructose and standard diets in methylnitrosourea (MNU)-induced ER+mammary cancers: Altered carcinogenesis, differential effects of metformin, and metabolomic differences

The MNU-induced model of ER+ mammary cancers in Sprague-Dawley rats has routinely been employed in screening for chemopreventive agents. We recently reported that metformin was ineffective in preventing mammary cancers in rats on a standard diet (Thompson, et al, Cancer Prev. Res, 8, 231-9, 2015). In this study, we evaluated the carcinogenic response in Vehicle-treated rats and rats receiving Metformin (150 mg/Kg BW/day) on standard Teklad or...