• References (46)
  • Citations (1)
Published on May 1, 2017in Inflammation Research3.06
Marie Korabecna10
Estimated H-index: 10
(Charles University in Prague),
Vladimir Tesar34
Estimated H-index: 34
(Charles University in Prague)
Introduction Neutrophil extracellular traps (NETs) are formed by activated neutrophils during the process of NETosis in which the nuclear material is released into extracellular space, including DNA molecules, citrullinated histones, and neutrophil granule enzymes, such as elastase. This material forms networks that are able not only to physically entrap bacteria but also to provide elevated concentration of bactericidal components. Over the last years, it has become clear that NETs can also be ...
Published on Dec 17, 2016in International Journal of Molecular Sciences4.18
Chih-Cheng Hsieh1
Estimated H-index: 1
Han-Shui Hsu20
Estimated H-index: 20
+ 1 AuthorsYann-Jang Chen1
Estimated H-index: 1
Circulating cell-free DNA (cfDNA) is a potential biomarker for cancer progression but its role is unclear in patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy. We investigated relationships between plasma cfDNA levels and clinicopathological parameters in ESCC patients. Eighty-one ESCC patients who received esophagectomy were enrolled. Plasma samples from these patients and 95 normal controls were collected. DNA copy numbers were measured by real-time quantitative PCR. ...
Published on Dec 1, 2016in Cell Death and Disease5.96
Gerben Marsman4
Estimated H-index: 4
Sacha Zeerleder27
Estimated H-index: 27
Brenda M. Luken15
Estimated H-index: 15
In inflammation, extensive cell death may occur, which results in the release of chromatin components into the extracellular environment. Individually, the purified chromatin components double stranded (ds)DNA and histones have been demonstrated, both in vitro and in vivo, to display various immunostimulatory effects, for example, histones induce cytotoxicity and proinflammatory signaling through toll-like receptor (TLR)2 and 4, while DNA induces signaling through TLR9 and intracellular nucleic ...
Mónica Villalba-Campos2
Estimated H-index: 2
(Del Rosario University),
Sandra Ramírez-Clavijo5
Estimated H-index: 5
(Del Rosario University)
+ 5 AuthorsLilian Chuaire-Noack3
Estimated H-index: 3
(Del Rosario University)
Background For several years, cell-free DNA has been emerging as an important biomarker for non-invasive diagnostic in a wide range of clinical conditions and diseases. The limited information available on the genotoxic effects associated with occupational exposure to car paints, as well as the fact that up-to-date there are not reports about cell-free DNA measurements for assessing this condition, led us to evaluate the DNA damage caused by the occupational exposure to organic solvents containe...
Published on Dec 1, 2016in Cell & Bioscience3.35
Jia‑Cheng Tang1
Estimated H-index: 1
(SRRSH: Sir Run Run Shaw Hospital),
Yi‑Li Feng1
Estimated H-index: 1
(ZJU: Zhejiang University)
+ 2 AuthorsXiu‑Jun Cai1
Estimated H-index: 1
(SRRSH: Sir Run Run Shaw Hospital)
Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early detection and precision treatment as well as prognosis of hepatocellular carcinoma (HCC). As ctDNA in HCC patients harbors the molecular characteristics of HCC tumor cells, ctDNA analysis in the blood ma...
Published on Oct 1, 2016in Biological Research For Nursing1.51
Mayu O. Frank3
Estimated H-index: 3
(NYU: New York University)
Introduction:As the U.S. population ages, the incidence of chronic disease will rise. Chronic diseases have been linked to chronic inflammation. The purpose of this review is to summarize the literature on cell-free DNA (cfDNA) in relation to inflammation.Methods:PubMed, EMBASE, and Web of Science were searched. Inclusion criteria were noninterventional studies on acute and chronic inflammation, autoimmunity, and infection published in English after 2000, conducted in humans using the fluorescen...
Published on Jun 16, 2016in PLOS ONE2.78
Xuezhi Zhou2
Estimated H-index: 2
(SYSU: Sun Yat-sen University),
Yantao Wei4
Estimated H-index: 4
(SYSU: Sun Yat-sen University)
+ 3 AuthorsShaochong Zhang5
Estimated H-index: 5
(SYSU: Sun Yat-sen University)
Age-related macular degeneration (AMD) is the major cause of loss of sight globally. There is currently no effective treatment available. Retinal pigment epithelial (RPE) cells are an important part of the outer blood-retina barrier and their death is a determinant of AMD. Propofol, a common clinically used intravenous anesthetic agent, has been shown to act as an efficacious neuroprotective agent with antioxidative and anti-inflammatory properties in vivo and in vitro. However, little is known ...
Published on Oct 1, 2015in American Journal of Transplantation7.16
E. M. J. Gielis1
Estimated H-index: 1
(University of Antwerp),
Kristien J. Ledeganck5
Estimated H-index: 5
(University of Antwerp)
+ 5 AuthorsMichael Eikmans24
Estimated H-index: 24
(LUMC: Leiden University Medical Center)
After organ transplantation, donor-derived cell-free DNA (ddcfDNA) can be detected in the recipient's blood and urine. Different ddcfDNA quantification techniques have been investigated but a major breakthrough was made with the introduction of digital droplet PCR and massive parallel sequencing creating the opportunity to increase the understanding of ddcfDNA kinetics after transplantation. The observations of increased levels of ddcfDNA during acute rejection and even weeks to months before hi...
Published on Sep 1, 2015in Nature Immunology23.53
Sanja Arandjelovic14
Estimated H-index: 14
Kodi S. Ravichandran6
Estimated H-index: 6
Billions of cells in the body die through apoptosis every day and are cleared by both professional and non-professional phagocytes. Arandjelovic and Ravichandran review how apoptotic cell clearance is critical for immune homeostasis.
Published on Jun 1, 2015in Coronary Artery Disease1.55
Lei Wang1
Estimated H-index: 1
Liang Qi Xie1
Estimated H-index: 1
+ 6 AuthorsJianbin Gong5
Estimated H-index: 5
Abstract Plasma nuclear and mitochondrial DNA (mtDNA) levels are altered in many diseases. However, it is not known whether they are also altered in acute myocardial infarction (AMI). In the present study, we examined plasma nuclear and mtDNA levels in the patients with AMI before and after a percutaneous coronary intervention (PCI) to explore their potential as biomarkers. Plasma nuclear and mtDNA levels were measured by quantitative PCR in 25 AMI patients, 25 non-myocardial infarction (MI) con...
Cited By1
Published on Jul 1, 2019in Critical Reviews in Oncology Hematology5.01
Javier Arzuaga-Mendez1
Estimated H-index: 1
Endika Prieto-Fernández4
Estimated H-index: 4
(UPV/EHU: University of the Basque Country)
+ 3 AuthorsAfrica Garcia-Orad16
Estimated H-index: 16
Abstract Cell-free DNA (cfDNA), which is DNA released from cells into the circulation, is one of the most promising non-invasive biomarkers in cancer. This approach could be of interest for the management of Diffuse Large B-Cell Lymphoma (DLBCL) patients, which is the most common non-Hodgkin lymphoma. Then, the aim of this systematic review was to define the utility of cfDNA in this disease. Selected articles were classified in four groups, depending on the aspects of cfDNA studied, i.e. concent...
Published on Feb 1, 2019in Transplant International3.53
Jia Shen (ZJU: Zhejiang University), Yang Zhou7
Estimated H-index: 7
(Jiangsu University)
+ 11 AuthorsGongda Yang (Jiangsu University)