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Serial perioperative cell‐free DNA levels in donors and recipients undergoing living donor liver transplantation

Published on Oct 1, 2017in Acta Anaesthesiologica Scandinavica2.228
· DOI :10.1111/aas.12947
K. Prakash1
Estimated H-index: 1
,
S. Aggarwal1
Estimated H-index: 1
+ 2 AuthorsC. K. Pandey1
Estimated H-index: 1
Abstract
  • References (46)
  • Citations (2)
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References46
Newest
#1Marie Korabecna (Charles University in Prague)H-Index: 11
#2Vladimir Tesar (Charles University in Prague)H-Index: 31
Introduction Neutrophil extracellular traps (NETs) are formed by activated neutrophils during the process of NETosis in which the nuclear material is released into extracellular space, including DNA molecules, citrullinated histones, and neutrophil granule enzymes, such as elastase. This material forms networks that are able not only to physically entrap bacteria but also to provide elevated concentration of bactericidal components. Over the last years, it has become clear that NETs can also be ...
8 CitationsSource
Circulating cell-free DNA (cfDNA) is a potential biomarker for cancer progression but its role is unclear in patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy. We investigated relationships between plasma cfDNA levels and clinicopathological parameters in ESCC patients. Eighty-one ESCC patients who received esophagectomy were enrolled. Plasma samples from these patients and 95 normal controls were collected. DNA copy numbers were measured by real-time quantitative PCR. ...
10 CitationsSource
#1Gerben Marsman (UvA: University of Amsterdam)H-Index: 4
#2Sacha Zeerleder (UvA: University of Amsterdam)H-Index: 27
Last. Brenda M. Luken (UvA: University of Amsterdam)H-Index: 17
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In inflammation, extensive cell death may occur, which results in the release of chromatin components into the extracellular environment. Individually, the purified chromatin components double stranded (ds)DNA and histones have been demonstrated, both in vitro and in vivo, to display various immunostimulatory effects, for example, histones induce cytotoxicity and proinflammatory signaling through toll-like receptor (TLR)2 and 4, while DNA induces signaling through TLR9 and intracellular nucleic ...
44 CitationsSource
#1Mónica Villalba-Campos (Del Rosario University)H-Index: 2
#2Sandra Ramírez-Clavijo (Del Rosario University)H-Index: 6
Last. Lilian Chuaire-Noack (Del Rosario University)H-Index: 4
view all 8 authors...
Background For several years, cell-free DNA has been emerging as an important biomarker for non-invasive diagnostic in a wide range of clinical conditions and diseases. The limited information available on the genotoxic effects associated with occupational exposure to car paints, as well as the fact that up-to-date there are not reports about cell-free DNA measurements for assessing this condition, led us to evaluate the DNA damage caused by the occupational exposure to organic solvents containe...
4 CitationsSource
#1Jia‑Cheng Tang (SRRSH: Sir Run Run Shaw Hospital)H-Index: 1
#2Yi‑Li Feng (ZJU: Zhejiang University)H-Index: 1
Last. Xiu‑Jun Cai (SRRSH: Sir Run Run Shaw Hospital)H-Index: 1
view all 5 authors...
Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early detection and precision treatment as well as prognosis of hepatocellular carcinoma (HCC). As ctDNA in HCC patients harbors the molecular characteristics of HCC tumor cells, ctDNA analysis in the blood ma...
8 CitationsSource
#1Xuezhi Zhou (SYSU: Sun Yat-sen University)H-Index: 2
#2Yantao Wei (SYSU: Sun Yat-sen University)H-Index: 5
Last. Shaochong Zhang (SYSU: Sun Yat-sen University)H-Index: 5
view all 6 authors...
Age-related macular degeneration (AMD) is the major cause of loss of sight globally. There is currently no effective treatment available. Retinal pigment epithelial (RPE) cells are an important part of the outer blood-retina barrier and their death is a determinant of AMD. Propofol, a common clinically used intravenous anesthetic agent, has been shown to act as an efficacious neuroprotective agent with antioxidative and anti-inflammatory properties in vivo and in vitro. However, little is known ...
6 CitationsSource
Introduction:As the U.S. population ages, the incidence of chronic disease will rise. Chronic diseases have been linked to chronic inflammation. The purpose of this review is to summarize the literature on cell-free DNA (cfDNA) in relation to inflammation.Methods:PubMed, EMBASE, and Web of Science were searched. Inclusion criteria were noninterventional studies on acute and chronic inflammation, autoimmunity, and infection published in English after 2000, conducted in humans using the fluorescen...
16 CitationsSource
#1E. M. J. Gielis (University of Antwerp)H-Index: 1
#2Kristien J. Ledeganck (University of Antwerp)H-Index: 5
Last. Michael Eikmans (LUMC: Leiden University Medical Center)H-Index: 24
view all 8 authors...
After organ transplantation, donor-derived cell-free DNA (ddcfDNA) can be detected in the recipient's blood and urine. Different ddcfDNA quantification techniques have been investigated but a major breakthrough was made with the introduction of digital droplet PCR and massive parallel sequencing creating the opportunity to increase the understanding of ddcfDNA kinetics after transplantation. The observations of increased levels of ddcfDNA during acute rejection and even weeks to months before hi...
55 CitationsSource
Billions of cells in the body die through apoptosis every day and are cleared by both professional and non-professional phagocytes. Arandjelovic and Ravichandran review how apoptotic cell clearance is critical for immune homeostasis.
197 CitationsSource
#1Lei WangH-Index: 1
#2Xie LH-Index: 1
Last. Gong JH-Index: 1
view all 8 authors...
Abstract Plasma nuclear and mitochondrial DNA (mtDNA) levels are altered in many diseases. However, it is not known whether they are also altered in acute myocardial infarction (AMI). In the present study, we examined plasma nuclear and mtDNA levels in the patients with AMI before and after a percutaneous coronary intervention (PCI) to explore their potential as biomarkers. Plasma nuclear and mtDNA levels were measured by quantitative PCR in 25 AMI patients, 25 non-myocardial infarction (MI) con...
32 CitationsSource
Cited By2
Newest
#1Stephen J. Bagley (UPenn: University of Pennsylvania)H-Index: 8
#2S. Ali Nabavizadeh (UPenn: University of Pennsylvania)H-Index: 2
Last. Erica L. Carpenter (UPenn: University of Pennsylvania)H-Index: 17
view all 20 authors...
Purpose: The clinical utility of plasma cell-free DNA (cfDNA) has not been assessed prospectively in patients with glioblastoma (GBM). We aimed to determine the prognostic impact of plasma cfDNA in GBM, as well as its role as a surrogate of tumor burden and substrate for next-generation sequencing (NGS). Experimental Design: We conducted a prospective cohort study of 42 patients with newly diagnosed GBM. Plasma cfDNA was quantified at baseline prior to initial tumor resection and longitudinally ...
2 CitationsSource
#1Javier Arzuaga-Mendez (UPV/EHU: University of the Basque Country)H-Index: 1
#2Endika Prieto-Fernández (UPV/EHU: University of the Basque Country)H-Index: 4
Last. Africa Garcia-Orad (UPV/EHU: University of the Basque Country)H-Index: 17
view all 6 authors...
Abstract Cell-free DNA (cfDNA), which is DNA released from cells into the circulation, is one of the most promising non-invasive biomarkers in cancer. This approach could be of interest for the management of Diffuse Large B-Cell Lymphoma (DLBCL) patients, which is the most common non-Hodgkin lymphoma. Then, the aim of this systematic review was to define the utility of cfDNA in this disease. Selected articles were classified in four groups, depending on the aspects of cfDNA studied, i.e. concent...
Source
#1Jia Shen (ZJU: Zhejiang University)H-Index: 1
#2Yang Zhou (Jiangsu University)H-Index: 8
Last. Rending Wang (ZJU: Zhejiang University)H-Index: 9
view all 14 authors...
1 CitationsSource