Match!

Income inequality, gene expression, and brain maturation during adolescence

Published on Dec 1, 2017in Scientific Reports4.011
· DOI :10.1038/s41598-017-07735-2
Nadine Parker1
Estimated H-index: 1
(U of T: University of Toronto),
Angelita Pui-Yee Wong4
Estimated H-index: 4
(U of T: University of Toronto)
+ 6 AuthorsTomáš Paus86
Estimated H-index: 86
Abstract
Income inequality is associated with poor health and social outcomes. Negative social comparisons and competition may involve the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in underlying some of these complex inter-relationships. Here we investigate brain maturation, indexed by age-related decreases in cortical thickness, in adolescents living in neighborhoods with differing levels of income inequality and household income. We examine whether inter-regional variations relate to those in glucocorticoid receptor (HPA) and androgen receptor (HPG) gene expression. For each sex, we used a median split of income inequality and household income (income-to-needs ratio) to create four subgroups. In female adolescents, the high-inequality low-income group displayed the greatest age-related decreases in cortical thickness. In this group, expression of glucocorticoid and androgen receptor genes explained the most variance in these age-related decreases in thickness across the cortex. We speculate that female adolescents living in high-inequality neighborhoods and low-income households may experience greater HPA and HPG activity, leading to steeper decreases in cortical thickness with age.
  • References (81)
  • Citations (3)
📖 Papers frequently viewed together
2 Citations
31 Citations
300 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References81
Newest
#1Derrek P. Hibar (SC: University of Southern California)H-Index: 37
#2Lars T. Westlye (Oslo University Hospital)H-Index: 53
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 89
view all 123 authors...
Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
108 CitationsSource
#1Angelita Pui-Yee Wong (U of T: University of Toronto)H-Index: 4
#2Leon French (U of T: University of Toronto)H-Index: 14
Last. Tomáš PausH-Index: 86
view all 9 authors...
Abstract Age-related decreases in cortical thickness observed during adolescence may be related to fluctuations in sex and stress hormones. We examine this possibility by relating inter-regional variations in age-related cortical thinning (data from the Saguenay Youth Study) to inter-regional variations in expression levels of relevant genes (data from the Allen Human Brain Atlas); we focus on genes coding for glucocorticoid receptor (NR3C1), androgen receptor (AR), progesterone receptor (PGR), ...
9 CitationsSource
#1Lianne Schmaal (VUmc: VU University Medical Center)H-Index: 22
#2Derrek P. Hibar (SC: University of Southern California)H-Index: 37
Last. Dick J. Veltman (VUmc: VU University Medical Center)H-Index: 69
view all 81 authors...
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with ha...
186 CitationsSource
#1Frank J. Elgar (McGill University)H-Index: 32
#2Geneviève Gariépy (McGill University)H-Index: 17
Last. Candace Currie (St And: University of St Andrews)H-Index: 48
view all 4 authors...
A prevailing hypothesis about the association between income inequality and poor health is that inequality intensifies social hierarchies, increases stress, erodes social and material resources that support health, and subsequently harms health. However, the evidence in support of this hypothesis is limited by cross-sectional, ecological studies and a scarcity of developmental studies. To address this limitation, we used pooled, multilevel data from the Health Behaviour in School-aged Children s...
22 CitationsSource
This Mini-Review describes sex differences in 66 quantitative characteristics of the brain and body measured in a community-based sample of 1,024 adolescents 12–18 years of age, members of the Saguenay Youth Study. Using an extensive phenotyping protocol, we have obtained measures in a number of domains, including brain structure, cognition, mental health, substance use, body composition, metabolism, cardiovascular reactivity, and life style. For each measure, we provide estimates of effect size...
15 CitationsSource
#1Luciane R. Piccolo (Columbia University)H-Index: 3
#2Emily C. Merz (CUMC: Columbia University Medical Center)H-Index: 11
Last. Kimberly G. Noble (Columbia University)H-Index: 3
view all 5 authors...
Recent findings indicate robust associations between socioeconomic status (SES) and brain structure in children, raising questions about the ways in which SES may modify structural brain development. In general, cortical thickness and surface area develop in nonlinear patterns across childhood and adolescence, with developmental patterns varying to some degree by cortical region. Here, we examined whether age-related nonlinear changes in cortical thickness and surface area varied by SES, as inde...
43 CitationsSource
#1Paul T. von Hippel (University of Texas at Austin)H-Index: 17
#2Samuel V. Scarpino (SFI: Santa Fe Institute)H-Index: 17
Last. Igor Holas (University of Texas at Austin)H-Index: 3
view all 3 authors...
Researchers often estimate income inequality by using data that give only the number of cases (e.g., families or households) whose incomes fall in “bins” such as 0 to ,999, 10,000 to 4,999, . . . , ≥$200,000. We find that popular methods for estimating inequality from binned incomes are not robust in small samples, where popular methods can produce infinite, undefined, or arbitrarily large estimates. To solve these and other problems, we develop two improved estimators: a robust Pareto mi...
13 CitationsSource
#1Satwant Kaur (Brunel University London)H-Index: 4
#2Alice Baynes (Brunel University London)H-Index: 5
Last. Susan Jobling (Brunel University London)H-Index: 45
view all 7 authors...
Gastropod mollusks have been proposed as alternative models for male reproductive toxicity testing, due to similarities in their reproductive anatomy compared to mammals, together with evidence that endocrine disrupting chemicals can cause effects in some mollusks analogous to those seen in mammals. To test this hypothesis, we used the freshwater pulmonate snail, Biomphalaria glabrata, for which various genetic tools and a draft genome have recently become available, to investigate the effects o...
10 CitationsSource
#1Zdenka PausovaH-Index: 36
#2Tomáš Paus (MIND Institute)H-Index: 86
Last. Suzanne Veillette (UQAC: Université du Québec à Chicoutimi)H-Index: 12
view all 11 authors...
The Saguenay Youth Study (SYS) is a two-generational study of adolescents and their parents (n = 1029 adolescents and 962 parents) aimed at investigating the aetiology, early stages and trans-generational trajectories of common cardiometabolic and brain diseases. The ultimate goal of this study is to identify effective means for increasing healthy life expectancy. The cohort was recruited from the genetic founder population of the Saguenay Lac St Jean region of Quebec, Canada. The participants u...
15 CitationsSource
#1Simon Ducharme (Montreal Neurological Institute and Hospital)H-Index: 14
#2Matthew D. Albaugh (UVM: University of Vermont)H-Index: 16
Last. Sherif Karama (Montreal Neurological Institute and Hospital)H-Index: 29
view all 8 authors...
Abstract Several reports have described cortical thickness (CTh) developmental trajectories, with conflicting results. Some studies have reported inverted-U shape curves with peaks of CTh in late childhood to adolescence, while others suggested predominant monotonic decline after age 6. In this study, we reviewed CTh developmental trajectories in the NIH MRI Study of Normal Brain Development, and in a second step, evaluated the impact of post-processing quality control (QC) procedures on identif...
96 CitationsSource
Cited By3
Newest
#1Ruoxi Ding (PKU: Peking University)H-Index: 1
#2Lei Zhang (PKU: Peking University)H-Index: 9
Last. Xiao-Yingzheng (PKU: Peking University)H-Index: 24
view all 5 authors...
Background Previous studies have suggested that socio-environmental factors interact with genetic risk in the genesis of schizophrenia. This study aimed to investigate the relationship between income, income inequality and schizophrenia and its heterogeneity among different geographic scales and subgroups. Methods We used data from the Second China National Sample Survey on Disability (2006). The sample consisted of 1 909 205 participants aged 18 years or older. Individuals who were suspected to...
Source
#1Hwa Mi Yang (KU: Korea University)
#2Jina Choo (KU: Korea University)H-Index: 17
ABSTRACTLittle evidence exists on the role of work-to-family conflict (WFC) in explaining socioeconomic inequality in self-rated health (SRH). We examined the association between socioeconomic stat...
Source
#1Nadine Parker (U of T: University of Toronto)H-Index: 1
#2Didac Vidal-Piñeiro (University of Oslo)H-Index: 10
Last. Tomáš Paus (U of T: University of Toronto)H-Index: 86
view all 32 authors...
Source
#1Bastian Greshake Tzovaras (LBNL: Lawrence Berkeley National Laboratory)H-Index: 5
#2Athina Tzovara (HWNI: Helen Wills Neuroscience Institute)H-Index: 12
The success of personalized medicine does not only rely on methodological advances but also on the availability of data to learn from. While the generation and sharing of large data sets is becoming increasingly easier, there is a remarkable lack of diversity within shared datasets, rendering any novel scientific findings directly applicable only to a small portion of the human population. Here, we are investigating two fields that have been majorly impacted by data sharing initiatives, neurosci...
Source