Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope
Abstract
Experimental CMV-based vaccine vectors expressing a single MHC class I-restricted high-avidity epitope provided strong, T cell-dependent protection against viruses or tumors. In this study we tested the low-avidity epitope KCSRNRQYL, and show that a mouse CMV (MCMV) vector provides complete immune control of recombinant vaccinia virus expressing the same epitope if KCSRNRQYL is expressed within the immediate-early MCMV gene ie2 The same epitope...
Paper Details
Title
Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope
Published Date
Sep 1, 2017
Journal
Volume
199
Issue
5
Pages
1737 - 1747
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Notes
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