Bayesian association scan reveals loci associated with human lifespan and linked biomarkers
Abstract
The enormous variation in human lifespan is in part due to a myriad of sequence variants, only a few of which have been revealed to date. Since many life-shortening events are related to diseases, we developed a Mendelian randomization-based method combining 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs. A Bayesian association scan, informed by these priors, for parental age of death in the UK Biobank study ( n...
Paper Details
Title
Bayesian association scan reveals loci associated with human lifespan and linked biomarkers
Published Date
Jul 27, 2017
Journal
Volume
8
Issue
1
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