Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

Cell64.50
Volume: 170, Issue: 3, Pages: 457 - 469
Published: Jul 27, 2017
Abstract
Summary null G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction with arrestins, whose binding promotes receptor internalization and signaling through G protein-independent pathways. High-affinity arrestin binding requires receptor phosphorylation, often at the receptor's C-terminal tail. Here, we report an X-ray free electron laser (XFEL) crystal structure of the rhodopsin-arrestin complex, in which the...
Paper Details
Title
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
Published Date
Jul 27, 2017
Journal
Volume
170
Issue
3
Pages
457 - 469
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