Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Abstract
Tumor growth relies on efficient DNA repair to mitigate the detrimental impact of DNA damage associated with excessive cell division. Modulating repair factor function, thus, provides a promising strategy to manipulate malignant growth. Here, we identify the ubiquitin-specific protease USP21 as a positive regulator of BRCA2, a key mediator of DNA repair by homologous recombination. USP21 interacts with, deubiquitinates and stabilizes BRCA2 to...
Paper Details
Title
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Published Date
Jul 26, 2017
Journal
Volume
8
Issue
1
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