Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
Abstract
Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell) and mesenchymal (osteoblast lineage, chondrocyte) cell types. The cellular mechanisms by which estrogen acts on bone are still a matter of controversy. By...
Paper Details
Title
Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
Published Date
Jul 25, 2017
Journal
Volume
7
Issue
1
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