Measures of Biologic Age in a Community Sample Predict Mortality and Age-Related Disease: The Framingham Offspring Study

We tested the association of biologic age (BA) measures constructed from different types of biomarkers with mortality and disease in a community-based sample. In Framingham Offspring participants at Exams 7 (1998–2001, mean age 62 ± 10) and 8 (2005–2008, mean age 67 ± 9), we used the Klemera–Doubal method to estimate clinical BA and inflammatory BA and computed the difference (∆age) between BA and CA. Clinical ∆age was computed at Exam 2...