Functional annotation of chemical libraries across diverse biological processes
Abstract
Profiling of over 13,000 compounds against yeast gene deletion mutants, defining the differential responses on cells, reveals chemical-genetic interactions that can be used to predict compound function and their target pathways. Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells in the presence of a compound, revealing chemical-genetic interactions...
Paper Details
Title
Functional annotation of chemical libraries across diverse biological processes
Published Date
Jul 24, 2017
Journal
Volume
13
Issue
9
Pages
982 - 993
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