Abstract 319: Cardiac Deficiency of AMPK Exacerbates Heart Hypertrophy by Pressure Overload

Introduction: Heart hypertrophy caused by pressure overload is characterized by the activation of adenosine monophosphate-activated protein kinase (AMPK), which is a major energy sensor in the heart. However, the anti-inflammatory effect of AMPK has not been determined in the hypertrophy model. Activated protein C (APC) is a vitamin-K dependent plasma serine protease which inhibits blood clotting, and APC is an endogenous AMPK agonist. This...