Match!

Interaction of Newly Platinum(II) with Tris(2-carboxyethyl)phosphine Complex with DNA and Model Lipid Membrane

Published on Oct 1, 2017in The Journal of Membrane Biology1.75
· DOI :10.1007/s00232-017-9972-z
Hanna Pruchnik11
Estimated H-index: 11
(Wroclaw University of Environmental and Life Sciences),
Teresa Kral9
Estimated H-index: 9
(Wroclaw University of Environmental and Life Sciences),
Martin Hof33
Estimated H-index: 33
Abstract
Structural properties of plasmid DNA and model lipid membrane treated with newly synthesized platinum(II) complex cis-[PtCl2{P(CH2CH2COOH)3}2] (cis-DTCEP for short) were studied and compared with effects of anticancer drug cisplatin, cis-[Pt(NH3)2Cl2] (cis-DDP for short). Time Correlated Single Photon Counting Fluorescence Correlation Spectroscopy (TCSPC-FCS) was employed to study interactions between those platinum complexes and DNA. The TCSPC-FCS results suggest that bonding of cis-DTCEP derivative to DNA leads to plasmid strain realignment towards much more compact structure than in the case of cis-DDP. Application of both differential scanning calorimetry and infrared spectroscopy to platinum complexes/DPPC showed that cis-DTCEP slightly increases the phospholipid’s main phase transition temperature resulting in decreased fluidity of the model membrane. The newly investigated compound—similarly to cis-DDP—interacts mainly with the DPPC head group however not only by the means of electrostatic forces: this compound probably enters into hydrophilic region of the lipid bilayer and forms hydrogen bonds with COO groups of glycerol and PO2 − group of DPPC.
  • References (33)
  • Citations (3)
References33
Newest
#1Marta Henklewska (Wroclaw University of Environmental and Life Sciences)H-Index: 2
#2Aleksandra Pawlak (Wroclaw University of Environmental and Life Sciences)H-Index: 6
Last.Bożena Obmińska-Mrukowicz (Wroclaw University of Environmental and Life Sciences)H-Index: 9
view all 4 authors...
#1Ana Catarina Alves (University of Porto)H-Index: 4
#2Daniela Ribeiro (University of Porto)H-Index: 15
Last.Salette Reis (University of Porto)H-Index: 36
view all 4 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 7 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Tadeusz Lis (UWr: University of Wrocław)H-Index: 31
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 19
view all 3 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 3 authors...
#1Shaloam R. Dasari (JSU: Jackson State University)H-Index: 2
#2Paul B. Tchounwou (JSU: Jackson State University)H-Index: 36
Cited By3
Newest
#1Marta Henklewska (Wroclaw University of Environmental and Life Sciences)H-Index: 2
#2Aleksandra Pawlak (Wroclaw University of Environmental and Life Sciences)H-Index: 6
Last.Bożena Obmińska-Mrukowicz (Wroclaw University of Environmental and Life Sciences)H-Index: 9
view all 6 authors...
#1Marcelo Echeverri (UAM: Autonomous University of Madrid)H-Index: 1
#2Amparo Alvarez-Valdés (UAM: Autonomous University of Madrid)H-Index: 13
Last.Adoración G. Quiroga (UAM: Autonomous University of Madrid)H-Index: 21
view all 6 authors...
View next paperModifications of the DNA secondary structure upon platinum binding: a proposed model