A lysosome-targeted BODIPY as potential NIR photosensitizer for photodynamic therapy

As an indispensable organelle, lysosomes play critical role in cell digestion and are closely relate to cell death and apoptosis. Photosensitizers that target to lysosomes are extremely important to photodynamic therapy. Herein, we report an excellent BODIPY based photosensitizer MBDP for lysosome targeting NIR photosensitizer. MBDP exhibits excellent PDT efficiency with low IC50 of 0.2 μM compared to the classical photosensitizer Ce6 (IC50 =...