Effect of dietary polyphenols on fructose uptake by human intestinal epithelial (Caco-2) cells

Intake of high-fructose products is associated with metabolic syndrome development. We investigated if dietary polyphenols can interfere with fructose absorption by the human intestinal epithelial Caco-2 cell line. Acutely, several polyphenols induced a significant decrease (15–20%) in 14C-fructose uptake. Chronically, 14C-fructose uptake was also affected by polyphenols; quercetin, chrysin and apigenin (100 µM) were the most effective (±25%...