Match!

The ZJU index is a powerful index for identifying NAFLD in the general Chinese population

Published on Oct 1, 2017in Acta Diabetologica2.996
· DOI :10.1007/s00592-017-1024-8
Linman Li1
Estimated H-index: 1
(CQMU: Chongqing Medical University),
Wenyi You1
Estimated H-index: 1
,
Wei Ren9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
Sources
Abstract
Aims The ZJU index is a novel model for detecting non-alcoholic fatty liver disease (NAFLD) that it is calculated based on combination of the body mass index, fasting plasma glucose, triglycerides, and the serum alanine aminotransferase-to-aspartate transaminase ratio. We aimed to evaluate the diagnostic accuracy of the ZJU index in detecting NAFLD in the Chinese population.
  • References (24)
  • Citations (4)
📖 Papers frequently viewed together
180 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References24
Newest
#1A. L. Sberna (French Institute of Health and Medical Research)H-Index: 1
#2Benjamin Bouillet (French Institute of Health and Medical Research)H-Index: 12
Last. Jean-Michel Petit (French Institute of Health and Medical Research)H-Index: 23
view all 12 authors...
Aims To evaluate the application of the recently proposed recommendations by the European Association for the Study of the Liver, European Association for the Study of Diabetes and European Association for the Study of Obesity for the diagnosis, treatment and follow-up of non-alcoholic fatty liver disease in people with Type 2 diabetes. Methods A total of 179 people with Type 2 diabetes were included in this study. Liver fat content (assessed using proton magnetic resonance spectroscopy), fatty ...
83 CitationsSource
#1George Boon-Bee Goh (NUS: National University of Singapore)H-Index: 7
#2Arthur J. McCullough (Cleveland Clinic)H-Index: 64
Nonalcoholic fatty liver disease (NAFLD) remains among the most common liver diseases worldwide, with increasing prevalence in concert with the obesity and metabolic syndrome epidemic. The evidence on the natural history, albeit with some ambiguity, suggests the potential for some subsets of NAFLD to progress to cirrhosis, liver-related complications and mortality with fibrosis being the most important predictor of hard long-term endpoints such as mortality and liver complications. In this setti...
44 CitationsSource
#1Jinghua WangH-Index: 3
#2Chengfu XuH-Index: 22
Last. Youming LiH-Index: 37
view all 7 authors...
Non-alcoholic fatty liver disease (NAFLD) is an important health issue worldwide. We aimed to develop a simple model to determine the presence of NAFLD in a Chinese population. A cross-sectional study with 9602 subjects was conducted. Potential predictors were entered into a stepwise logistic regression analysis to obtain the model. We used 148 patients with liver biopsy to validate this model. The model, named the ZJU index, was developed based on body mass index (BMI), fasting plasma glucose (...
23 CitationsSource
#1Mary Eugenia Rinella (NU: Northwestern University)H-Index: 25
Importance Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis affect approximately 30% and 5%, respectively, of the US population. In patients with nonalcoholic steatohepatitis, half of deaths are due to cardiovascular disease and malignancy, yet awareness of this remains low. Cirrhosis, the third leading cause of death in patients with nonalcoholic fatty liver disease, is predicted to become the most common indication for liver transplantation. Objectives To illustrat...
686 CitationsSource
#1Chengfu XuH-Index: 22
#2Chaohui YuH-Index: 30
Last. Youming LiH-Index: 37
view all 6 authors...
Prevalence and Risk Factors for the Development of Nonalcoholic Fatty Liver Disease in a Nonobese Chinese Population: the Zhejiang Zhenhai Study
79 CitationsSource
#1Naga Chalasani (IU: Indiana University)H-Index: 75
#2Zobair M. Younossi (Inova Fairfax Hospital)H-Index: 84
Last. Arun J. Sanyal (VCU: Virginia Commonwealth University)H-Index: 102
view all 8 authors...
These recommendations are based on the following: (1) a formal review and analysis of the recently published world literature on the topic [Medline search up to June 2011]; (2) the American College of Physicians’ Manual for Assessing Health Practices and Designing Practice Guidelines; (3) guideline policies of the three societies approving this document; and (4) the experience of the authors and independent reviewers with regards to NAFLD. Intended for use by physicians and allied health profess...
1,891 CitationsSource
#1Chaohui Yu (ZJU: Zhejiang University)H-Index: 30
#2Chengfu Xu (ZJU: Zhejiang University)H-Index: 22
Last. Youming Li (ZJU: Zhejiang University)H-Index: 37
view all 6 authors...
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. The two linked studies presented herein aimed to identify and verify new biomarkers for NAFLD. Methods: First, 70 serum samples were analyzed using proteomics approaches to identify potential biomarkers for NAFLD. Second, a total of 6944 initial NAFLD-free subjects were followed up for 3 years to evaluate the predictive value of hemoglobin for NAFLD. Results: In the first study...
53 CitationsSource
#1Ruben Hernaez (Johns Hopkins University)H-Index: 19
#2Mariana Lazo (Johns Hopkins University)H-Index: 29
Last. Jeanne M. Clark (Johns Hopkins University)H-Index: 61
view all 7 authors...
Fatty liver is the accumulation of fat (i.e., macro-vesicular steatosis) within the hepatic parenchyma. Nonalcoholic fatty liver disease (NAFLD), the presence of fat infiltration in the liver in the absence of excessive alcohol consumption and other causes of liver disease, is the most common cause of fatty liver, with a prevalence as high as 30% in many populations.1 NAFLD may lead to fibrosis,2 cirrhosis,3 liver cancer,4,5 liver failure requiring liver transplant,6 and mortality7, and it is as...
447 CitationsSource
#1Gregory C. Vernon (Inova Health System)H-Index: 1
#2Ancha Baranova (Inova Health System)H-Index: 32
Last. Zobair M. Younossi (Inova Health System)H-Index: 84
view all 3 authors...
SUMMARY Background Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, and its worldwide prevalence continues to increase with the growing obesity epidemic. This study assesses the epidemiology of NAFLD in adults based on clinical literature published over the past 30 years. Aim To review epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults based on clinical literature published over the past 30 years....
1,550 CitationsSource
#1Giliola CaloriH-Index: 36
#2Guido Lattuada (University of Milan)H-Index: 21
Last. Gianluca Perseghin (University of Milan)H-Index: 40
view all 10 authors...
A fatty liver, which is a common feature in insulin-resistant states, can lead to chronic liver disease. It has been hypothesized that a fatty liver can also increase the rates of non–hepatic-related morbidity and mortality. Therefore, we wanted to determine whether the fatty liver index (FLI), a surrogate marker and a validated algorithm derived from the serum triglyceride level, body mass index, waist circumference, and γ-glutamyltransferase level, was associated with the prognosis in a popula...
127 CitationsSource
Cited By4
Newest
#1Inhwan Lee (SKKU: Sungkyunkwan University)H-Index: 5
#2Eunmi Park (ISMMS: Icahn School of Medicine at Mount Sinai)
Last. Jinkyung Cho (SKKU: Sungkyunkwan University)
view all 3 authors...
Abstract The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels. The aim of this study was to investigate the relationship between NAFLD risk and serum vitamin D levels combined with physical fitness in elderly adults using a non-invasive diagnostic approach. We enrolled 533 Korean older adults (80.8% women), aged...
Source
Source
#1Chia-Po Fu (NTU: National Taiwan University)H-Index: 8
#2Hira Ali (University of Pittsburgh)H-Index: 1
Last. Erin E. Kershaw (University of Pittsburgh)H-Index: 15
view all 6 authors...
Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the western world and is highly associated with multiple cardiometabolic complications. The Zhejiang University (ZJU) index was first developed to predict NAFLD in Chinese populations, where it was shown to have better predictive value than other currently used indices. The aims of the present study were to 1) determine the diagnostic accuracy of ZJU index in identifying NAFLD in a well-phenotyped ...
Source
#1Asieh Mansour (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
#2Mohammad Reza Mohajeri-Tehrani (Tehran University of Medical Sciences)H-Index: 12
Last. Azita Hekmatdoost (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 22
view all 8 authors...
Aims In patients with type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and liver fibrosis is frequent and presumably associated with increased cardiovascular disease risk and mortality. The objective was to investigate risk factors associated with hepatic fibrosis in patients with type 2 diabetes and NAFLD to provide a basis for the prevention and treatment.
1 CitationsSource
#1Jinghua Wang (ZJU: Zhejiang University)H-Index: 3
#2Liang Ma (ZJU: Zhejiang University)H-Index: 1
Last. Chengfu Xu (ZJU: Zhejiang University)H-Index: 22
view all 8 authors...
Non-invasive assessment was widely used to identify the risk of non-alcoholic fatty liver disease (NAFLD) among individuals with increased metabolic risks. This study aimed to investigate the prospective relationship between ZJU index and the development of NAFLD in a Chinese population.A cohort of 6310 initially NAFLD-free participants was enrolled in this prospective study. Abdominal ultrasound was used to diagnosis NAFLD. NAFLD incidence was calculated among participants with different baseli...
2 CitationsSource
#1Jinzhou Zhu (Soochow University (Suzhou))H-Index: 1
#2Mingqing He (Soochow University (Suzhou))H-Index: 1
Last. Weichang Chen (Soochow University (Suzhou))H-Index: 1
view all 7 authors...
: Various noninvasive algorithms have been developed for predicting the presence of nonalcoholic fatty liver disease (NAFLD). The evaluation of the indexes' diagnostic performance has been reported in Europe and Asia over the past decade; however, external validation of them in China is rare. This study was aimed to evaluate various indexes for NAFLD in western China. It was a retrospective cross-sectional study, using data from a large-scale health check-up project at Sichuan provincial hospita...
2 CitationsSource